Vaccine-preventable diseases in the U.S. - statistics & facts

Vaccine-preventable diseases are those for which an effective vaccine exists. Vaccines, used worldwide as a preventative healthcare measure, provide protection against a range of common and/or serious diseases. Since the 1980s, the use of vaccines has reduced the incidence of these diseases (in the case of smallpox leading to disease eradication), and in turn has prevented approximately 2.5 million deaths a year. Importantly, it has also reduced the rate of child mortality. The global health community, with the backing of the World Health Organization, is committed to working towards a world in which all individuals and communities enjoy lives free from vaccine-preventable diseases.

Recommended vaccinations

The World Health Organization has a list of recommended vaccinations, and it is up to national immunization managers and key decision-makers, chairs and members of national advisory committees on immunization to determine the policy for each country. This is determined based on where each disease is common, the level of health care access, the cost of vaccines, and issues with vaccine availability, transport and storage for the given region. The number and timing of doses, cost of vaccination and whether immunization is mandatory or recommended differs between countries around the world. In some countries, vaccination is also a requirement for admission to schools. In the United States, the immunization schedule has been recommended by the Advisory Committee on Immunization Practices, and approved by the Centers for Disease Control and Prevention.

U.S. vaccination schedule

The number of diseases on immunization schedules around the world has grown rapidly since the mid-1980s, as new vaccinations have been developed. Currently on the schedule in the United States are vaccinations against chickenpox, diphtheria, Haemophilus influenzae type b, hepatitis A and B, influenza, measles, mumps, pertussis, polio, pneumococcal, rotavirus, rubella, and tetanus. The World Health Organization tracks the vaccination coverage and prevalence of vaccine-preventable diseases worldwide, and although immunization refusals have recently increased slightly in some regions, overall vaccine coverage remains high.

This text provides general information. Statista assumes no liability for the information given being complete or correct. Due to varying update cycles, statistics can display more up-to-date data than referenced in the text.

Year that smallpox was eradicated: 1980

Global DTP1 vaccination coverage: 89%

Diseases prevented by DTP1: Diphtheria, tetanus, and pertussis

Editor’s Picks Current statistics on this topic

Top 10 causes of death in the U.S. in 1900 and 2022 (per 100,000 population)

Diseases

Major causes of death in the U.S.: 1900 and 2022

Routine vaccination coverage globally as of 2022, by vaccine type*

Prevention

Global vaccination coverage in 2022, by vaccine type

Reported cases of rubella in the U.S. from 1998 to 2021, by year

Diseases

Number of rubella cases in the U.S. from 1998 to 2021, by year

Overview

Basic Statistic Number of vaccine-preventable disease cases worldwide 1980-2021, by disease
Number of vaccine-preventable disease cases worldwide 1980-2021, by disease
Reported cases of vaccine-preventable diseases worldwide from 1980 to 2021, by disease
Premium Statistic Global vaccination coverage in 2022, by vaccine type
Global vaccination coverage in 2022, by vaccine type
Routine vaccination coverage globally as of 2022, by vaccine type*
Basic Statistic Vaccination coverage Americas vs globally 2022, by vaccine type
Vaccination coverage Americas vs globally 2022, by vaccine type
Routine vaccination coverage in the Americas compared to worldwide as of 2022, by vaccine type*
Premium Statistic Vaccination coverage among U.S. adolescents as of 2022, by age
Vaccination coverage among U.S. adolescents as of 2022, by age
Percentage of adolescents in the U.S. who had received select vaccinations as of 2022, by age
Basic Statistic Cases of vaccine-preventable diseases in the U.S. from 1980 to 2021, by disease
Cases of vaccine-preventable diseases in the U.S. from 1980 to 2021, by disease
Reported cases of select vaccine-preventable diseases in the U.S. from 1980 to 2021, by disease
Basic Statistic Cases of infectious diseases before and after the use of vaccines U.S. 2017
Cases of infectious diseases before and after the use of vaccines U.S. 2017
Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2017
Premium Statistic Major causes of death in the U.S.: 1900 and 2022
Major causes of death in the U.S.: 1900 and 2022
Top 10 causes of death in the U.S. in 1900 and 2022 (per 100,000 population)

Global disease incidence

Premium Statistic Incidence of tuberculosis worldwide by region 2021
Incidence of tuberculosis worldwide by region 2021
Incidence of tuberculosis worldwide in 2021, by region (per 100,000 population)
Basic Statistic Positive influenza cases per week worldwide in 2021, by type
Positive influenza cases per week worldwide in 2021, by type
Reported cases of influenza per week in 2021 worldwide, by type
Premium Statistic Number of measles cases worldwide from 1980 to 2021, by region
Number of measles cases worldwide from 1980 to 2021, by region
Reported cases of measles worldwide from 1980 to 2021, by region
Basic Statistic Number of mumps cases worldwide from 1999 to 2021, by region
Number of mumps cases worldwide from 1999 to 2021, by region
Confirmed cases of mumps worldwide from 1999 to 2021, by region
Basic Statistic Number of rubella cases worldwide from 1999 to 2021, by region
Number of rubella cases worldwide from 1999 to 2021, by region
Reported cases of rubella worldwide from 1999 to 2021, by region
Premium Statistic Number of cases of diphtheria worldwide from 1980 to 2021, by region
Number of cases of diphtheria worldwide from 1980 to 2021, by region
Confirmed cases of diphtheria worldwide from 1980 to 2021, by region
Basic Statistic Number of tetanus cases worldwide from 1980 to 2022, by region
Number of tetanus cases worldwide from 1980 to 2022, by region
Reported cases of tetanus worldwide from 1980 to 2022, by region
Premium Statistic Number of pertussis (whooping cough) cases worldwide from 1980 to 2021, by region
Number of pertussis (whooping cough) cases worldwide from 1980 to 2021, by region
Reported cases of pertussis (whooping cough) worldwide from 1980 to 2021, by region
Basic Statistic Number of polio cases worldwide from 1980 to 2021, by region
Number of polio cases worldwide from 1980 to 2021, by region
Reported cases of polio worldwide from 1980 to 2021, by region
Basic Statistic Number of smallpox cases worldwide 1920-1980
Number of smallpox cases worldwide 1920-1980
Reported number of smallpox cases globally between 1920 and 1980
Basic Statistic Number of countries where smallpox was eradicated in nature 1872-1977
Number of countries where smallpox was eradicated in nature 1872-1977
Number of countries in which naturally occurring cases of smallpox were eradicated between 1872 and 1977

Tuberculosis (BCG Immunization)

Premium Statistic Number of new cases of tuberculosis in the U.S. 1960-2019
Number of new cases of tuberculosis in the U.S. 1960-2019
Number of new cases of tuberculosis in the U.S. from 1960 to 2019*
Premium Statistic Rate of new cases of tuberculosis in the U.S. 1960-2019
Rate of new cases of tuberculosis in the U.S. 1960-2019
New cases of tuberculosis per 100,000 population in the U.S. from 1960 to 2019*
Premium Statistic New cases of tuberculosis in the U.S. 2023, by state
New cases of tuberculosis in the U.S. 2023, by state
New cases of tuberculosis per 100,000 population in the U.S. in 2023, by state
Basic Statistic New cases of tuberculosis in the U.S. from 2016 to 2023, by national origin
New cases of tuberculosis in the U.S. from 2016 to 2023, by national origin
Tuberculosis case count in the U.S. from 2016 to 2023, by national origin*
Basic Statistic Death rate for tuberculosis in the U.S. 1960-2021
Death rate for tuberculosis in the U.S. 1960-2021
Tuberculosis death rate in the United States from 1960 to 2021 (per 100,000 population)

Influenza (HiB Immunization)

Premium Statistic Flu vaccine coverage in the U.S. 2014-2023, by age
Flu vaccine coverage in the U.S. 2014-2023, by age
Percentage of individuals with a flu vaccine in the U.S. from 2014 to 2023, by age
Premium Statistic Percentage of U.S. older people who received influenza vaccination 2010-2023
Percentage of U.S. older people who received influenza vaccination 2010-2023
Percentage of older people who received an influenza vaccination during the flu season in the U.S. from 2010 to 2023
Basic Statistic Number of influenza cases in the United States from 2010-2023
Number of influenza cases in the United States from 2010-2023
Estimated number of influenza cases in the United States from 2010 to 2023 (in millions)
Premium Statistic Number of influenza hospitalizations in the United States from 2010-2023
Number of influenza hospitalizations in the United States from 2010-2023
Number of influenza hospitalizations in the United States from 2010 to 2023
Basic Statistic Number of influenza deaths in the United States from 2010-2023
Number of influenza deaths in the United States from 2010-2023
Number of influenza deaths in the United States from 2010 to 2023
Basic Statistic Deaths by influenza and pneumonia in the U.S. 1950-2019
Deaths by influenza and pneumonia in the U.S. 1950-2019
Deaths by influenza and pneumonia in the U.S. from 1950 to 2019 (per 100,000 population)
Basic Statistic Number of influenza vaccinations needed to prevent one hospitalization U.S. 2018-2019
Number of influenza vaccinations needed to prevent one hospitalization U.S. 2018-2019
Number of influenza vaccinations needed to prevent one influenza A (H1N1)-associated hospitalization in the U.S. from 2018 to 2019, by age group
Premium Statistic Number of deaths prevented by influenza vaccinations U.S. 2022-2023, by age
Number of deaths prevented by influenza vaccinations U.S. 2022-2023, by age
Number of influenza A- and B-associated deaths prevented by influenza vaccination in the U.S. from 2022 to 2023, by age group

Measles Mumps and Rubella (MMR Immunization)

Basic Statistic MMR vaccination rate among U.S. children aged 19-35 months 1995-2017
MMR vaccination rate among U.S. children aged 19-35 months 1995-2017
Percentage of children aged 19-35 months who are vaccinated against measles, mumps and rubella (MMR) in the U.S. from 1995 to 2017
Basic Statistic New cases of measles in the U.S. 1950-2022
New cases of measles in the U.S. 1950-2022
Number of new cases of measles (rubeola) in the U.S. from 1950 to 2022
Premium Statistic Rate of new cases of measles in the U.S. 1950-2019
Rate of new cases of measles in the U.S. 1950-2019
Rate of new measles (rubeola) cases in the U.S. from 1950 to 2019 (per 100,000 population)
Basic Statistic Number of measles cases in the U.S. in 2020, by region
Number of measles cases in the U.S. in 2020, by region
Number of cases of measles reported in the United States in 2020, by region*
Basic Statistic New cases of mumps in the U.S. 1970-2019
New cases of mumps in the U.S. 1970-2019
New cases of mumps per 100,000 population in the U.S. from 1970 to 2019
Basic Statistic Number of mumps cases in the U.S. in 2020, by region
Number of mumps cases in the U.S. in 2020, by region
Number of cases of mumps reported in the United States in 2020, by region
Premium Statistic Number of rubella cases in the U.S. from 1998 to 2021, by year
Number of rubella cases in the U.S. from 1998 to 2021, by year
Reported cases of rubella in the U.S. from 1998 to 2021, by year

Diphtheria Tetanus and Pertussis (DTP3 Immunization)

Premium Statistic DTP3 immunization coverage in the U.S. from 2000 to 2022
DTP3 immunization coverage in the U.S. from 2000 to 2022
Diphtheria tetanus toxoid and pertussis (DTP3) immunization coverage among one-year-olds in the U.S. 2000-2022*
Premium Statistic New cases of diphtheria in the U.S. 1950-2019
New cases of diphtheria in the U.S. 1950-2019
New cases of diphtheria per 100,000 population in the U.S. from 1950 to 2019
Premium Statistic Number of diphtheria deaths in the U.S. from 1990 to 2019
Number of diphtheria deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by diphtheria in the United States from 1990 to 2019, by year
Basic Statistic Number of U.S. tetanus cases from 1980 to 2022, by year
Number of U.S. tetanus cases from 1980 to 2022, by year
Reported cases of tetanus in the United States from 1980 to 2022, by year
Basic Statistic Number of tetanus deaths in the U.S. from 1990 to 2019
Number of tetanus deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by tetanus in the United States from 1990 to 2019, by year
Basic Statistic Cases of pertussis in the U.S. 1950-2019
Cases of pertussis in the U.S. 1950-2019
New cases of pertussis (whooping cough) per 100,000 population in the U.S. from 1950 to 2019
Basic Statistic Rate of pertussis among U.S. population by state 2018
Rate of pertussis among U.S. population by state 2018
Pertussis rate in the United States as of 2018, by state (new cases per 100,000 population)
Basic Statistic Number of whooping cough deaths in the U.S. from 1990 to 2019
Number of whooping cough deaths in the U.S. from 1990 to 2019
Estimated number of deaths caused by whooping cough (pertussis) in the United States from 1990 to 2019, by year

Hepatitis A and B

Premium Statistic Hepatitis B immunization coverage in the U.S. among one-year-olds, 2000-2022
Hepatitis B immunization coverage in the U.S. among one-year-olds, 2000-2022
Hepatitis B (HepB3) immunization coverage among one-year-olds in the United States from 2000 to 2022, by year
Premium Statistic Rate of hepatitis B infections in the U.S. in 2021, by state
Rate of hepatitis B infections in the U.S. in 2021, by state
Rate of viral hepatitis B infections in the U.S. in 2021, by state (per 100,000 population)
Premium Statistic Rate of hepatitis B-related deaths in the U.S. in 2021, by age
Rate of hepatitis B-related deaths in the U.S. in 2021, by age
Rate of viral hepatitis B-related deaths in the U.S. in 2021, by age (per 100,000 population)
Basic Statistic Hepatitis A infection rate in the U.S. in 2021, by state
Hepatitis A infection rate in the U.S. in 2021, by state
Rate of viral hepatitis A infection in the U.S. in 2021, by state (per 100,000 population)
Basic Statistic Rate of hepatitis A-related deaths in the U.S. in 2021, by age
Rate of hepatitis A-related deaths in the U.S. in 2021, by age
Rate of viral hepatitis A-related deaths in the U.S. in 2021, by age (per 100,000 population)
Premium Statistic New cases of hepatitis A and B 1970-2019
New cases of hepatitis A and B 1970-2019
New cases of hepatitis A and B per 100,000 population in the U.S. from 1970 to 2019
Premium Statistic Rate of viral hepatitis-related deaths in the U.S. from 2017-2021, by type
Rate of viral hepatitis-related deaths in the U.S. from 2017-2021, by type
Rate of viral hepatitis-related deaths in the U.S. from 2017 to 2021, by type (per 100,000 population)

Human Papilloma Virus (HPV Immunization)

Basic Statistic HPV vaccine coverage among U.S. adolescents as of 2022, by age
HPV vaccine coverage among U.S. adolescents as of 2022, by age
Percentage of adolescents in the U.S. who had received an HPV vaccine as of 2022, by age*
Basic Statistic Share of U.S. college students vaccinated against HPV as of fall 2023, by gender
Share of U.S. college students vaccinated against HPV as of fall 2023, by gender
Percentage of college students in the U.S. who had been vaccinated against Human Papillomavirus (HPV), as of fall 2023, by gender
Basic Statistic U.S. adults who received the recommended doses of the HPV vaccine 2013-2018 by gender
U.S. adults who received the recommended doses of the HPV vaccine 2013-2018 by gender
Share of adults aged 18-26 in the U.S. who received the recommended number of doses of human papillomavirus vaccine between 2013 and 2018, by gender
Premium Statistic Number of cancer cases that were caused by HPV in the U.S. 2016-2020, by site
Number of cancer cases that were caused by HPV in the U.S. 2016-2020, by site
Number of select cancer cases that were probably caused by HPV in the U.S. per year from 2016 to 2020, by site*
Premium Statistic Percentage of select cancers that were caused by HPV in the U.S. 2016-2020, by gender
Percentage of select cancers that were caused by HPV in the U.S. 2016-2020, by gender
Percentage of HPV-related cancers that were probably caused by HPV in the U.S. per year from 2016 to 2020, by gender*
Premium Statistic Percentage of select cancers that were caused by HPV in the U.S. 2016-2020, by site
Percentage of select cancers that were caused by HPV in the U.S. 2016-2020, by site
Percentage of select cancers that were probably caused by HPV in the U.S. per year from 2016 to 2020, by site*
Basic Statistic U.S. rate of new alcohol-associated cancers 2016-2020, by state
U.S. rate of new alcohol-associated cancers 2016-2020, by state
Rate of new alcohol-associated cancers in the United States from 2016 to 2020, by state (per 100,000 people)

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Key figures

The most important key figures provide you with a compact summary of the topic of "Vaccine-preventable diseases in the U.S." and take you straight to the corresponding statistics.

Number of influenza hospitalizations in the 2022-2023 U.S. flu season
360,000
Detailed statistics
Number of influenza hospitalizations in the United States from 2010-2023
Percent of those over 65 who have had the flu vaccine in the U.S. in the past year
69.7%
Detailed statistics
Flu vaccine coverage in the U.S. 2014-2023, by age
U.S. influenza mortality rate (per 100,000 population)
12.3
Detailed statistics
Deaths by influenza and pneumonia in the U.S. 1950-2019

MMR vaccination coverage among children in the U.S.
91.5%
Detailed statistics
MMR vaccination rate among U.S. children aged 19-35 months 1995-2017
U.S. region with the highest rate of measles
Pacific
Detailed statistics
Number of measles cases in the U.S. in 2020, by region
Mumps cases in the U.S. in 2019
3,780
Detailed statistics
New cases of mumps in the U.S. 1970-2019

Age group with the highest rate of deaths from hepatitis B in the U.S.
65-74 years
Detailed statistics
Rate of hepatitis B-related deaths in the U.S. in 2021, by age
U.S. state with the highest hepatitis A infection rate
Arkansas
Detailed statistics
Hepatitis A infection rate in the U.S. in 2021, by state
New cases of hepatitis B in the U.S. 2019
3,544
Detailed statistics
New cases of hepatitis in the U.S. 1970-2019